In the parallel universe where I have the ability to give out Nobel Prizes at whim, I think I'd have a whole category for subway advertising defacement. Sometimes I am moved to tears just by the sight of a grinning model with an uneven Salvador Dali mustache or blackened teeth, as much from the basic silliness as the appreciation for such clean & classic naughtiness. The prize for this category would be shaped like a 1930s Daffy Duck holding a Sharpie and grinning wickedly. While he drew a mustache on Alfred Nobel's profile.
Today's winner, though, was seen on a poster for an adult ed program of some sort; the original imagery centered on a glowing brain lifting a barbell, and at bottom had a young man raising his fist and whooping at the sky, joyous of his newfound intellectual might or whatever. Anyway, someone put a word balloon over his head: Curse you, Evil Brain!!